A diet with a moderately low content of animal fats can be recommended for most people. For example, the diet proposed by the American Heart Association leads to a decrease in cholesterol in the blood by almost 15% and slightly reduces the frequency of heart attacks. At the same time, people with a hereditary predisposition to heart attack and stroke, who, therefore, may be particularly sensitive to the damaging effects of LDL, should adhere to a diet that severely restricts the intake of cholesterol and saturated fatty acids, even if their LDL concentration in the blood is close to the average, "normal" level. Further research is likely to reveal other factors affecting a person's sensitivity to the effects of excess LDL.

Finally, the use of substances that increase the content of LDL receptors may be beneficial for at least some people — those who do not suffer from familial hypercholesterolemia, but whose number of LDL receptors is reduced due to improper nutrition or other factors. If it is proven that such drugs prevent a food-induced decrease in the number of LDL receptors and, moreover, are safe for long-term use, then one day many people will be able to eat their steak without thinking that it shortens their lives.

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Exogenous and endogenous lipid transport pathways

The cholesterol contained in food is absorbed by the intestinal walls and, together with triglycerides, is packed into chylomicrons. In the capillaries of fat and muscle tissues, the essential bonds in triglycerides are hydrolyzed by lipoprotein lipase (LP lipase) and fatty acids are removed. When cholesterol-enriched chylomicron residues enter the liver, they bind to specific receptors and penetrate into liver cells. The cholesterol contained in them is secreted from the liver into the intestine as part of bile acids or forms very low density lipoprotein (LDL) particles together with triglycerides. These particles are released into the blood, which begins the endogenous lipid transport pathway. Triglycerides are again removed in the capillaries of fat and muscle, as a result of which VLDL are converted into intermediate density lipoproteins (LPP). Some LPP bind to LDL receptors and are absorbed by liver cells, and those that remain in the bloodstream turn into LDL. Most of the LDL particles bind to their receptors on liver cells and other tissues and are eliminated from circulation. Cholesterol released from cells binds to high—density lipoproteins (HDL) and is esterified by cholesterol-cytin acyltransferase (HLAT). These esters pass into LPP, and then into the LDL formed from them and are eventually captured by cells. 1xBet Best Betting Offers in India All you have to do is provide the 1xbet promo code india when registering your new 1xBet account and you can receive a 130% first deposit match bonus as much as ₹42900! Registration at 1xBet India is easy with a few different sign-up methods. Betting sites introduce various bonuses for new and regular punters. These could be the welcome bonus for new players, free bet offers, a reload or a cashback offer on specific days of the week. Players can also win exclusive bonuses on their birthdays or referral rewards. Also, many sites have a VIP program to reward their regular customers.